# 🚀 Default High-Quality Case Prompt Template

Copy and adapt the following template to activate OsteoMatrix's full diagnostic capabilities:

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**Case for OsteoMatrix Expert Analysis**

**Patient:** [Age]-year-old [male/female]
**Anatomic Site:** [Exact bone or soft tissue location, e.g., distal femoral metaphysis, deep soft tissue of the posterior compartment of the thigh]
**Clinical History:** [Pain for X weeks/months, history of trauma, known genetic syndrome, prior radiation or chemotherapy, systemic symptoms]
**Imaging Summary:** [Key radiographic/CT/MRI features including matrix mineralization pattern, zone of transition, cortical destruction, soft tissue extension, periosteal reaction, size]
**Gross Description (if available):** [Color, consistency, necrosis, relationship to bone or neurovascular structures]

**Histologic Description (H&E):**
Provide a detailed narrative or structured bullets covering:
- Architecture and growth pattern
- Cell morphology (spindle, epithelioid, round, pleomorphic, etc.)
- Matrix production (osteoid, cartilage, collagen, myxoid)
- Cytologic atypia, mitoses (per 10 HPF), necrosis, vascular invasion
- Any special features (rosettes, giant cells, inflammatory infiltrate, etc.)

**Ancillary Studies Already Performed:**
- Immunohistochemistry (list every antibody with result and distribution):
- Molecular / Cytogenetic studies (FISH, RT-PCR, NGS fusion panel, mutation analysis):

**Specific Questions (optional):**
- What is your leading diagnosis and why?
- What are the top three differentials and the single best way to distinguish each?
- Are there additional stains or molecular tests you would order next?
- Any diagnostic pitfalls specific to this presentation?

Please render your complete expert analysis using the full OsteoMatrix protocol (SOUL + SKILL + diagnostic workflow).

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**Specialized Trigger Prompts (use when appropriate):**

- "Perform a point-by-point differential diagnosis between low-grade central osteosarcoma and desmoplastic fibroma in this 25-year-old patient with a metaphyseal lesion."
- "Interpret the following IHC panel in a 19-year-old male with a diaphyseal tibial permeative lesion showing membranous CD99 and nuclear NKX2.2: [list results]."
- "What is the most efficient and highest-yield molecular test for a myxoid spindle cell tumor in the deep soft tissue of the leg of a 45-year-old woman, and which entities are you considering?"
- "Review these features for a possible parosteal osteosarcoma versus reactive bone formation and advise on next steps."