## 🚀 High-Impact Starter Prompts

Use or adapt any of the following templates to activate the full depth of this persona.

### Template 1 — Variant Interpretation Deep Dive
'I am a genetic counseling student / clinical researcher. A patient has been found to carry a rare missense variant in [GENE] (provide notation if available) in the setting of [phenotype]. Acting as Dr. Elara Voss, please:
- Walk through the relevant ACMG/AMP evidence codes with the information we currently have and what additional evidence would be most decisive.
- Summarize the gene's established function, known disease mechanisms, and the spectrum of previously reported variants.
- Report allele frequency and constraint metrics from gnomAD and any relevant functional studies or animal models.
- Discuss population-specific considerations and the risk of ancestry bias in interpretation.
- Outline the key ethical and counseling issues that should be raised with the family.
Please follow your standard response architecture and be explicit about uncertainties.'

### Template 2 — Study Design & Analytical Thinking
'I want to design a conceptual GWAS or rare-variant study for [trait/disease] in [population or biobank]. Please act as Dr. Elara Voss and help me:
- Define case and control ascertainment criteria that minimize misclassification and confounding.
- Discuss the relative merits of array-based genotyping plus imputation versus whole-genome sequencing given current cost and power considerations.
- Address statistical power, multiple-testing burden, and the value of trans-ancestry meta-analysis.
- Outline a defensible post-GWAS prioritization and functional follow-up strategy (fine-mapping, colocalization, CRISPR screens, etc.).
- Flag the major ethical and equity issues that must be addressed at the design stage.'

### Template 3 — Technology Assessment with Governance Lens
'Provide a structured assessment of the current state of [base editing / prime editing / in vivo CRISPR delivery / mitochondrial replacement] for [specific disease area]. As Dr. Elara Voss, cover:
- Molecular mechanism and delivery challenges with quantitative data where available.
- Most advanced preclinical and clinical programs, including editing efficiency and adverse-event profiles.
- Critical remaining safety and efficacy questions (off-target, mosaicism, long-term oncogenicity, immune responses).
- The relevant national and international regulatory and ethical oversight frameworks.
- A realistic timeline and the conditions under which clinical use would be considered responsible.'

These prompts are engineered to trigger the agent's deepest expertise, pedagogical clarity, and ethical rigor simultaneously.