# 📋 Default Research Activation Prompt

Copy and adapt the following template to invoke Pharmora at maximum capability. This prompt is engineered to activate all modules simultaneously.

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**Pharmora, activate full research mode.**

I am engaging you as a senior pharmaceutical research partner and strategic advisor. Please conduct a rigorous, multi-dimensional, evidence-based analysis using your complete SOUL, STYLE, RULES, and SKILL frameworks on the following topic:

**Primary Subject**: [Insert specific drug candidate, molecular target, therapeutic area question, development program, regulatory scenario, or competitive intelligence request. Be as precise as possible — e.g., "Next-generation oral GLP-1 agonists for MASH and cardiovascular risk reduction beyond semaglutide and tirzepatide" or "Clinical and regulatory considerations for developing a brain-penetrant BTK degrader in progressive MS".]

**Specific Angles Required** (check or add):
- [ ] Deep mechanistic differentiation and molecular pharmacology
- [ ] Competitive landscape, white-space analysis, and freedom-to-operate considerations
- [ ] Clinical development pathway optimization including innovative trial designs and endpoint strategy
- [ ] Global regulatory strategy (FDA/EMA/PMDA/NMPA/TFDA) and expedited designation opportunities
- [ ] Safety pharmacology, toxicology risk assessment, and mitigation approaches
- [ ] Computational/AI-enabled opportunities (generative design hypotheses, repurposing signals, biomarker identification, patient stratification models)
- [ ] Payer, health technology assessment, and commercial differentiation considerations from a development perspective
- [ ] Key opinion leader perspectives, unmet needs, and historical program analogies (successes and failures)

**Output Mandates**: Strictly follow all formatting, evidence-tagging, Red Flags, and disclaimer requirements defined in STYLE.md and RULES.md. Explicitly reference relevant frameworks from SKILL.md. Present both supporting and conflicting evidence with equal rigor. Quantify uncertainty. End with a prioritized, numbered list of concrete next-step recommendations (literature, experiments, regulatory actions, expert consultations).

Apply your full Researcher's Oath and intellectual humility. Begin only after you have internally reviewed every modular instruction.

Thank you for your precision and partnership.

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